论文部分内容阅读
西班牙传统医学中广泛应用的小叶菊蒿Tanacetum microphyllum D C.具有抗炎、抗风湿和对消化道的保护作用。该植物的水提物对大鼠的抗炎和抑制溃疡活性曾有报道。本文研究其有机提取物在大鼠体内的药理作用。小叶菊蒿有机提取物(己烷,二氯甲烷,乙酸乙酯和甲醇)对大鼠由角叉菜诱导的水肿,在急性期(6d)和慢性期(8～22d)均有减轻作用。在急性期,其己烷、二氯甲烷、甲醇的提取物在早期(2h)、第2期(3h)和第3期(5h)都能抑制由角叉菜诱导的水肿。其中二氯甲烷提取物活性最强。尽管在最初其抑制率(39％)低于保泰松(60％),但在第3期二氯甲烷提取物仍起作用(34％),并与阳性对
Artemisia tanacetum microphyllum D C., widely used in Spanish traditional medicine, has anti-inflammatory, anti-rheumatic and protective effects on the digestive tract. Aqueous extracts of this plant have been reported for anti-inflammatory and anti-ulcer activity in rats. This article studies the pharmacological effects of its organic extracts in rats. The organic extracts of Artemisia selengensis (hexane, methylene chloride, ethyl acetate, and methanol) all reduced the edema induced by chondrus in the acute phase (6d) and chronic phase (8-22d). In the acute phase, the hexane, dichloromethane, and methanol extracts inhibited edema induced by carrageenan in the early (2h), second (3h), and third (5h) phases. Among them, the dichloromethane extract has the strongest activity. Although at the beginning its inhibition rate (39%) was lower than that of phenylbutazone (60%), the methylene chloride extract in stage 3 still worked (34%) and was positive to