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急性高胆固醇血症(急性 HCA)能增强家兔急性心肌梗塞(AMI)再灌注后血液多形核中性粒细胞(PMN)聚集率和活性率,加重前列腺环素(PGI_2)和血栓素 A_2(TxA_2)平衡紊乱和增加 PMN在缺血心肌的聚集、浸润,从而加重 AMI 再灌注损伤及功能障碍。应用布洛芬抑制 PMN 功能,调节PGI_2和 TxA_2平衡,减少 PMN 在缺血心肌聚集、浸润,可显著减轻急性 HCA 家兔 AMI 再灌注损伤和改善心功能。提示急性 HCA 时,PMN 是加重家兔 AMI 再灌注损伤的重要因素。
Acute hypercholesterolemia (acute HCA) can increase blood polymorphonuclear polymorphonuclear neutrophil (PMN) aggregation rate and activity rate after acute myocardial infarction (AMI) reperfusion in rabbits, aggravating prostacyclin (PGI_2) and thromboxane A_2 (TxA_2) Balancing disorders and increased PMN accumulation and infiltration in the ischemic myocardium aggravate AMI reperfusion injury and dysfunction. Application of ibuprofen to inhibit PMN function, regulate the balance of PGI 2 and TxA 2 , reduce PMN aggregation and infiltration in ischemic myocardium, can significantly reduce AMI reperfusion injury and improve cardiac function in acute HCA rabbits. When prompted by acute HCA, PMN is an important factor in aggravating rabbit AMI reperfusion injury.