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目的:观察洛铂联合局部热疗胸腔灌注治疗恶性胸腔积液的疗效和不良反应。方法:入组56例恶性胸腔积液患者,分为治疗组30例,对照组26例,全组患者给予胸腔置管,胸水引流彻底后,治疗组给予洛铂30mg/m2溶于5%葡萄糖50ml、IL-2 100万IU胸腔灌注,每周1次,2次为一疗程,同时给予热疗,每周3次,10次为1疗程。对照组无热疗。结果:A组控制胸水有效率为74.1%,B组52%,(P<0.05)。结论:热疗联合胸腔灌注化疗治疗恶性胸腔积液有协同作用。
Objective: To observe the efficacy and side effects of lobaplatin combined with local hyperthermia and pleural perfusion in the treatment of malignant pleural effusion. Methods: Fifty-six patients with malignant pleural effusion were divided into treatment group (n = 30) and control group (n = 26). All patients were given thoracic tube. Thrombus drainage was complete. After treatment, 50ml, IL-2 1000000 IU pleural perfusion, once a week, 2 times for a course of treatment, given hyperthermia, 3 times a week, 10 times for a course of treatment. Control group without hyperthermia. Results: The effective rate of pleural effusion in group A was 74.1% and in group B 52% (P <0.05). Conclusion: Hyperthermia combined with thoracic perfusion chemotherapy has a synergistic effect on malignant pleural effusion.