Rat embryonic stem cells create new era in development of genetically manipulated rat models

• 作 者: Kazushi Kawaharada Masaki Kawa
• 机 构: ResearchandDevelopmentDivision,DivisionofMolecularandCellularMedicine
• 出 处: 世界干细胞杂志：英文版（电子版）
• 发表日期: 2015年7期
• 关键词: EMBRYONIC stem cells TRANSGENIC RAT Embryonic stem cells Transgenic rat

Embryonic stem(ES) cells are isolated from theinner cell mass of a blastocyst, and are used for the generation of gene-modified animals. In mice, the transplantation of gene-modified ES cells into recipient blastocysts leads to the creation of gene-target