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目的探讨膀胱浆细胞样变异型尿路上皮癌的临床病理特征、鉴别诊断。方法运用光镜、特殊染色及免疫组化染色对1例浆细胞样变异型尿路上皮癌进行观察并复习文献。结果瘤细胞呈浆细胞样特征弥漫分布,胞浆嗜酸性或透亮,核大、偏位、深染。黏膜固有层及浅肌层见瘤细胞弥漫浸润。免疫组化:瘤细胞CK20、CK7、CK5、CK18、CD138、EMA(+),E-cadherin、p63、CD38、LCA和vimentin,S-100.Desmin,MyoD1(-)。结论浆细胞样变异型尿路上皮癌罕见,具有浆细胞样特征,需与恶性黑色素瘤、横纹肌肉瘤、浆细胞瘤等肿瘤相鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of bladder plasma cell-like variant urothelial carcinoma. Methods One case of plasma cell-like variant urothelial carcinoma was observed by light microscopy, special staining and immunohistochemical staining, and the literature was reviewed. Results The tumor cells showed diffuse distribution of plasmacytoid features, eosinophilic cytoplasm or translucent, large nucleus, deviation, deep staining. Mucosal lamina propria and superficial muscle cells see diffuse infiltration. Immunohistochemistry: tumor cells CK20, CK7, CK5, CK18, CD138, EMA (+), E-cadherin, p63, CD38, LCA and vimentin, S-100.Desmin, MyoD1 (-). Conclusion Plasmacytoid variant urothelial carcinoma is rare and has plasmacytoid features. It needs to be differentiated from malignant melanoma, rhabdomyosarcoma and plasmacytoma.