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目的:评价国产腺苷临床应用安全性及腺苷负荷心肌灌注显像对冠心病的诊断价值。方法:对51例临床疑诊冠心病患者,分别静脉注射腺苷,注射3 min末,静脉注射核素显像剂99Tcm-MIBI 925 MBq,1~1.5 h行心肌灌注断层显像,分析患者在腺苷注入后的血流动力学改变、副作用发生情况。经半年以上随访排除或确诊冠心病,评价腺苷负荷心肌灌注显像对冠心病的诊断价值。结果:腺苷输注后,86.3%(44/51)患者出现各种副作用,停药后均很快缓解。腺苷负荷试验心肌灌注显像诊断冠心病的敏感性90.9%,特异性71.4%,准确性88.2%,阳性预测值95.2%,阴性预测值55.6%。结论:国产腺苷可安全地应用于负荷心肌灌注显像。腺苷负荷心肌灌注显像诊断冠心病敏感性较高,具有重要的临床应用价值。
Objective: To evaluate the clinical application of adenosine safety and adenosine stress myocardial perfusion imaging in the diagnosis of coronary heart disease. Methods: Fifty-one patients with clinically suspected coronary heart disease were treated with adenosine intravenously and intravenous injection of 99Tcm-MIBI 925 MBq intravenously at the end of 3 min, and myocardial perfusion tomography at 1 to 1.5 h after intravenous injection. Adenosine hemodynamic changes after injection, the incidence of side effects. After more than six months follow-up to exclude or confirm coronary heart disease, adenosine stress myocardial perfusion imaging in the diagnosis of coronary heart disease. Results: After adenosine infusion, 86.3% (44/51) patients showed various side effects and relieved quickly after withdrawal. Adenosine stress test myocardial perfusion imaging diagnosis of coronary heart disease sensitivity 90.9%, specificity 71.4%, accuracy 88.2%, positive predictive value 95.2%, negative predictive value 55.6%. Conclusion: Domestic adenosine can be safely applied to myocardial perfusion imaging. Adenosine stress myocardial perfusion imaging diagnosis of coronary heart disease higher sensitivity, has important clinical value.