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目的和方法：本实验给孕期自发性高血压大鼠（ＳＨＲ）服用卡托普利（Ｃａｐ），观察对其子鼠动脉血管平滑肌细胞（ＶＳＭＣ）内钙离子浓度（［Ｃａ２＋］ｉ）、细胞生长、ＤＮＡ合成的影响。结果：孕期给予Ｃａｐ治疗，可使子代ＳＨＲ动脉ＶＳＭＣ的［Ｃａ２＋］ｉ明显低于不加处理的ＳＨＲ对照组（２０８．３７±３１．３４ｖｓ２７４．３９±５３．６５）ｎｍｏｌ／Ｌ，Ｐ＜００５；血清诱导下的细胞生长速度及ＤＮＡ合成也显著受抑（Ｐ＜００１）。结论：胚胎形成期可能是ＳＨＲ高血压发生、发展过程中的重要时期，在此期经Ｃａｐ干预能够减弱其发病，降低应激状态下升压的易感性。
Objectives and Methods: In this study, captopril was administered to spontaneously hypertensive rats (SHR) during pregnancy to observe the changes of calcium ion concentration ([Ca2 +] i) in arterial smooth muscle cells (VSMCs) Growth, DNA synthesis. Results: [Ca2 +] i in SHR arteries of offspring was significantly lower than that of SHR control (208.37 ± 31.34 vs 274.39 ± 53.65 nmol / L, P < 0 05; serum-induced cell growth rate and DNA synthesis was significantly inhibited (P <0 01). CONCLUSION: Embryogenesis may be an important period in the development and progression of SHR. During this period, Cap intervention can reduce its incidence and reduce the stress-induced susceptibility to vasopressin.