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目的:探讨逍遥散合六君子汤联合丙硫氧嘧啶治疗甲状腺功能亢进(简称甲亢)的临床疗效。方法:将符合纳入标准的84例甲亢患者随机分为治疗组和对照组。对照组予丙硫氧嘧啶片口服,治疗组在对照组基础上予逍遥散合六君子汤口服。观察比较两组中医证候积分、甲状腺功能、血清相关抗体指标及疗效。结果:治疗组总有效率为97.6%,高于对照组的80.9%(P<0.05);两组治疗后各时间点中医证候积分均低于治疗前(P<0.05);在治疗后组间不同时间点比较中,治疗组中医证候积分均低于对照组(P<0.05)。治疗后两组TSH含量均高于治疗前,FT3和FT4含量均低于治疗前(P<0.05);治疗后治疗组TSH含量高于对照组,FT3和FT4含量低于对照组(P<0.05)。两组患者治疗后血清TGAb和TPOAb的含量均低于治疗前(P<0.05);治疗后治疗组血清TGAb和TPOAb的含量均低于对照组(P<0.05)。结论:逍遥散合六君子汤联合丙硫氧嘧啶能够改善甲亢患者临床症状和甲状腺功能。
Objective: To investigate the clinical efficacy of Xiaoyaosan combined Liujunzi Decoction combined with propylthiouracil in the treatment of hyperthyroidism (referred to as hyperthyroidism). Methods: Eighty-four patients with hyperthyroidism who met the inclusion criteria were randomly divided into treatment group and control group. The control group was treated with propylthiouracil tablets orally, and the treatment group was given oral Xiaoyao Sanliu Junzitang on the basis of the control group. Observed and compared TCM syndrome score, thyroid function, serum antibody-related indicators and efficacy. Results: The total effective rate in the treatment group was 97.6%, which was higher than that in the control group (80.9%, P <0.05). The scores of TCM syndromes in the two groups after treatment were lower than those before treatment (P <0.05) Among different time points, the scores of TCM syndromes in the treatment group were lower than those in the control group (P <0.05). After treatment, the content of TSH in both groups were higher than those before treatment, and the levels of FT3 and FT4 in the two groups were lower than those before treatment (P <0.05); after treatment, the content of TSH in the treatment group was higher than that in the control group ). The levels of serum TGAb and TPOAb in both groups after treatment were lower than those before treatment (P <0.05). The levels of serum TGAb and TPOAb in the two groups were lower than those in the control group after treatment (P <0.05). Conclusion: Xiaoyaosan Liujunzi Decoction combined with propylthiouracil can improve clinical symptoms and thyroid function in patients with hyperthyroidism.