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AIM:Obesity has been proved as one of the main riskfactors for gastric cardia adenocarcinoma (GCA) in the West.The objective of our research was to evaluate therelationship between obesity and the risk of GCA in peoplefrom North China.METHODS:A total of 300 patients who had been diagnosedas GCA and had accepted surgical operation at Beijing CancerHospital from 1995 to 2002 were enrolled.Data werecollected from pathology materials and hospital records.Twohundred and fifty-eight healthy people who had acceptedhealth examination at the same hospital during the sameperiod were enrolled as controls.Height,weight and genderof them at the time of examination were also collected.Obesity was estimated by body mass index (BMI),computedas weight in kilograms per square surface area (Kg/m~2).The degree of obesity was determined by using BMI≤18.5,24-27.9 and ≥28 (Kg/m~2) as the cut-off points forunderweight/normal,overweight and obesity,respectively.Associations with obesity were estimated by odds ratios (ORs)and 95 % confidence intervals (CIs).All ORs were adjustedfor age and sex.RESULTS:The mean level of BMI was significantly lower inthe patient group than that in the control group.The ORSfor obesity in age groups 30-59 and 60-79 were 1.15 (95 %CI=0.37-3.65) and 0.16 (95 % CI=0.05-0.44) for males and0.78 (95 % CI=0.26-2.36) and 0.28 (95 % CI=0.04-2.05)for females,respectively.The ORs for underweight were2.42 (95 % CI=0.56-10.53) and 4.68 (95 % CI=1.13-19.40)for males in age subgroups 30-59 and 60-79 and 40.7 (95 %CI=9.32-177.92) for females older than 60 yrs.BMI wassignificantly associated with GCA (P<0.01).Underweightpeople were at high risk for GCA. .CONCLUSION:BMI is an Independent risk factory for GCA Underweight is possitively associated with GCA
AIM: Obesity has been proved as one of the main risk factors for gastric cardia adenocarcinoma (GCA) in the West. Objective of our research was to evaluate therelationship between obesity and the risk of GCA in people from North China. METHODS: A total of 300 patients who had been diagnosedas GCA and had accepted surgical operation at Beijing Cancer Hospital from 1995 to 2002 were enrolled.Data werecollected from pathology materials and hospital records.Twohundred and fifty-eight healthy people who had acceptedhealth examination at the same hospital during the sameperiod were enrolled as controls. Height, weight and gender of them at the time of examination were also collected. Obesity was estimated by body mass index (BMI), computedas weight in kilograms per square surface area (Kg / m ~ 2). degree of obesity was determined by using BMI ≤ 18.5, 24-27.9 and ≥ 28 (Kg / m ~ 2) as the cut-off points forunderweight / normal, overweight and obesity, respectively. Associations with obesity were estimated by o The dds ratios (ORs) and 95% confidence intervals (CIs). All ORs were adjusted for age and sex .RESULTS: The mean level of BMI was significantly lower inthe patient group than that in the control group. The ORS for obesity in age groups 30- 59 and 60-79 were 1.15 (95% CI = 0.37-3.65) and 0.16 (95% CI = 0.05-0.44) for males and 0.78 (95% CI = 0.26-2.36) and 0.28 2.05) for females, respectively.The ORs for underweight were 2.42 (95% CI = 0.56-10.53) and 4.68 (95% CI = 1.13-19.40) for males in age subgroups 30-59 and 60-79 and 40.7 % CI = 9.32-177.92) for females older than 60 yrs.BMI wassignificantly associated with GCA (P <0.01) .Underweightpeople were at high risk for GCA .CONCLUSION: BMI is an Independent risk factory for GCA Underweight is possitively associated with GCA