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目的探讨中老年人群代谢综合征及其组分和各组分联合作用与年龄相关白内障(ARC)的关系。方法采用1∶1匹配病例对照研究方法,对2010年12月—2011年12月接受手术治疗的360例病例组ARC患者和与病例同期入住相同医院、未患与白内障有关眼病的360例对照组患者进行问卷调查并对结果进行分析。结果病例组和对照组中糖尿病患者分别有104、55例,分别占28.89%和15.28%;高血压患者分别有131、96例,分别占36.39%和26.67%;高密度脂蛋白胆固醇(HDL-C)降低的分别有115、85例,分别占31.94%、23.61%,差异均有统计学意义(P<0.05);调整多种潜在性混杂因素后,糖尿病、高血压、HDL-C下降、甘油三酯(TG)升高、向心性肥胖均可使ARC发生的危险性增加;有代谢综合征者发生ARC的危险性是无代谢综合征者的2.213倍(OR=2.213,95%CI=1.012～4.837);具有≥3个代谢综合征组分的患者发生ARC的危险性明显升高(OR=2.667,95%CI=1.166～6.097);随着代谢综合征组分数量增加,发生ARC的危险性逐渐增高,线性趋势检验有统计学意义(χ2=10.326,P<0.001)。结论代谢综合征及其组分可使中老年人群发生ARC的危险性增加。
Objective To investigate the relationship between metabolic syndrome and the combined effects of its components and components with age-related cataract (ARC) in the middle-aged and elderly population. Methods A case-control study of 1: 1 was performed in 360 patients with ARC who underwent surgery from December 2010 to December 2011 and 360 control subjects who did not have eye disease related to cataract in the same hospital with the same patients Patients were surveyed and the results analyzed. Results There were 104 and 55 cases of diabetes in case group and control group respectively, accounting for 28.89% and 15.28% respectively. Hypertension patients were 131 and 96 cases, accounting for 36.39% and 26.67% respectively. High-density lipoprotein cholesterol (HDL- (P <0.05); After adjusting for a variety of potential confounders, diabetes, high blood pressure, HDL-C decreased, Increased triglycerides (TG), central obesity can make the risk of ARC increased; the risk of ARC with metabolic syndrome were 2.213 times those without metabolic syndrome (OR = 2.213, 95% CI = (OR = 2.667, 95% CI = 1.166 ~ 6.097). With the increase in the number of metabolic syndrome components, the occurrence of ARC was significantly higher in patients with more than 3 metabolic syndromes (Χ2 = 10.326, P <0.001). Conclusion Metabolic syndrome and its components may increase the risk of ARC in middle-aged and elderly people.