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表皮是人体的第一道防护屏障,对维持机体内环境的稳定起到了巨大的作用。表皮是新陈代谢频率较快的组织,正常机体中表皮的增殖、分化和凋亡处于一种动态的平衡中,一旦这种平衡失调,将会导致严重的皮肤病,因此,机体内应有一套精密的调控系统来调控这一过程。Notch、TGF-β和钙离子等信号通路可能参与了表皮的分化。
The epidermis is the body’s first protective barrier, to maintain the stability of the environment within the body has played a huge role. The epidermis is a tissue with a high frequency of metabolism. The proliferation, differentiation and apoptosis of the epidermis in the normal body are in a dynamic balance. Once this balance is imbalance, it will cause serious skin diseases. Therefore, the body should have a set of sophisticated Regulation and control system to regulate this process. The signaling pathways such as Notch, TGF-β and calcium ion may participate in the epidermal differentiation.