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Ru486又名Ru38486或Mifepristone,是一种人工合成的甾体化合物,化学结构式为17β-羟基-11β-[4-(N,N二甲胺基)-苯基]-17α-(丙炔-1)-△~(4,9)-雌甾二烯-3-酮。它有抗孕酮和糖皮质激素的作用,本文由于篇幅所限只讨论抗孕酮的作用。Ru486在靶细胞中与孕酮受体紧密结合,以致孕酮作用受阻,根据这一特点法国Rossel-Uclaf公司将Ru486制成抗早孕药物,自1982年以来进行了一系列临床实验,已取得较为满意的结果。现将作用机理方面的研究进展作一简要的阐述。
Ru486, also known as Ru38486 or Mifepristone, is a synthetic steroid compound with the chemical structure 17β-hydroxy-11β- [4- (N, N-dimethylamino) phenyl] -17α- ) - △ ~ (4,9) -estradiol-3-one. It has anti-progesterone and glucocorticoid effects, this article only discusses the role of anti-progesterone due to space limitations. Ru486 is tightly bound to progesterone receptor in target cells, so that the effect of progesterone is blocked. According to this feature, Rossel-Uclaf of France made Ru486 an anti-pregnancy drug and has carried out a series of clinical trials since 1982, Satisfying result. Now the mechanism of action research for a brief summary.