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目的探讨老年慢性阻塞性肺疾病(COPD)患者血清同型半胱氨酸(Hcy)水平及其临床意义。方法选取50例老年慢性阻塞性肺疾病急性加重期(AECOPD)住院患者(加重期组),48例老年稳定期COPD患者(稳定期组),同时设45例老年非COPD患者(对照组)。观察3组血清Hcy水平变化,测定其第1秒用力呼气容积(FEV1)、用力肺活量(FVC)。结果与对照组比较,加重期组和稳定期组血清Hcy水平、高Hcy血症检出率均显著增高差异具有统计学意义(P<0.01),而加重期组显著高于稳定期组差异具有统计学意义(P<0.05);在FEV1、FEV1/FVC,加重期组和稳定期组显著低于对照组差异具有统计学意义(P<0.01),而加重期组显著低于稳定期组差异具有统计学意义(P<0.05)。结论老年COPD患者血清Hcy水平升高,血清Hcy测定有助于预测COPD患者病情变化及预后。
Objective To investigate the serum homocysteine (Hcy) levels in elderly patients with chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods Fifty elderly hospitalized patients with exacerbation of chronic obstructive pulmonary disease (AECOPD), 48 elderly patients with stable COPD (stable group) and 45 elderly non-COPD patients (control group) were enrolled in this study. The changes of serum Hcy level in the three groups were observed. The forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured. Results Compared with the control group, the levels of Hcy and Hcy in the exacerbation group and the stable group were significantly increased (P <0.01), while those in the exacerbation group were significantly higher than those in the stable group (P <0.05). The FEV1, FEV1 / FVC, exacerbation group and stable group were significantly lower than the control group (P <0.01), while those in the exacerbation group were significantly lower than those in the stable group Statistically significant (P <0.05). Conclusion Serum Hcy levels are elevated in elderly patients with COPD and serum Hcy levels may be helpful in predicting the changes and prognosis of patients with COPD.