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目的:探讨白细胞介素-1(interleukin-1,IL-1),尤其是白细胞介素-1α(IL-1α)和白细胞介素-1受体拮抗剂(IL-1RA)基因多态性与东北地区汉族人群多发性硬化(multiple sclerosis,MS)的关系。方法:多聚酶链反应(PCR)进行IL-1α和IL-1RA基因多态性检测。结果:IL-1α和IL-1RA基因型分布及等位基因频率在MS和对照组间无显著性差异(P>0.05)。结论:IL-1α和IL-1RA基因多态性与MS易感性无相关性。
Objective: To investigate the relationship between interleukin-1 (IL-1), interleukin-1α (IL-1α) and interleukin-1 receptor antagonist Relationship between multiple sclerosis (MS) and Han population in northeast China. Methods: Polymerase chain reaction (PCR) detection of IL-1α and IL-1RA gene polymorphisms. Results: There was no significant difference in genotype distribution and allele frequencies of IL-1α and IL-1RA between MS and control groups (P> 0.05). Conclusion: The polymorphisms of IL-1α and IL-1RA have no correlation with susceptibility to MS.