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目的:比较伴或不伴高脂血症的系统性红斑狼疮(SLE)患者的狼疮性肝损害的构成比例,了解高脂血症与狼疮性肝损害的相关性。方法:收集SLE患者100例,根据高脂血症和狼疮性肝损害的诊断标准,将患者分为高脂血症组,非高脂血症组和肝损害组,非肝损害组,收集其相关临床数据进行比较分析。结果:1.高脂血症组发生肝损害的比例高于非高脂血症组(χ2=9.908,P=0.002);2.血脂水平中甘油三酯与γ-GT(r=0.366,P=0.000),碱性磷酸酶(r=0.241,P=0.018),强的松剂量(r=0.31,P=0.006),24 h尿蛋白定量(r=0.273,P=0.007)相关;TC与24 h尿蛋白定量(r=0.273,P=0.007)相关;HDL与γ谷氨酸转肽酶(r=-0.233,P=0.022),碱性磷酸酶(r=-0.265,P=0.009)相关;3.SLE活动组出现高脂血症的比例高于非活动组(χ2=6.986,P=0.008)。结论:长期的高脂血症可导致或加重SLE患者肝功能损害,高脂血症是狼疮性肝损害的危险因素之一。
OBJECTIVE: To compare the proportion of lupus patients with systemic lupus erythematosus (SLE) with or without hyperlipidemia to understand the association between hyperlipidemia and lupus liver damage. Methods: 100 patients with SLE were collected. According to the diagnostic criteria of hyperlipidemia and lupus liver damage, the patients were divided into hyperlipidemia group, non-hyperlipidemia group and liver injury group, Relevant clinical data for comparative analysis. The percentages of liver damage in hyperlipemia group were higher than those in non-hyperlipidemia group (χ2 = 9.908, P = 0.002) (R = 0.241, P = 0.018), prednisone dose (r = 0.31, P = 0.006) and 24 h urinary protein (r = 0.273, P = 0.007) (R = -0.233, P = 0.022), alkaline phosphatase (r = -0.265, P = 0.009) ; 3. The incidence of hyperlipidemia in the SLE group was higher than that in the inactive group (χ2 = 6.986, P = 0.008). Conclusion: Long-term hyperlipidemia can cause or aggravate liver dysfunction in patients with SLE. Hyperlipidemia is one of the risk factors of lupus liver damage.