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本文应用均相酶免疫法分别测定了６名老年慢性阻塞性能肺病患者口服氨茶碱达稳态及稳态后合用环丙沙星３ｄ，对合用前后茶碱的血药浓度及不良反应进行同步观察，以ＰＫＢＰ－Ｎ１程序包按一室模型对数据进行处理，并对结果进行统计分析，结果：环丙沙星使茶碱消除半衰期明显延长（Ｐ＜０．０５），导致血药浓度明显升高（Ｐ＜０．０５），而对分布容积及清除率均无明显影响（Ｐ＞０．０５）。二药合用期间患者出现茶碱不良反应。实验结果提示：环丙沙星抑制茶碱正常代谢，二者合用，应考虑减少茶碱的用量。
In this paper, the application of homogeneous enzyme immunoassay were measured in patients with chronic obstructive pulmonary disease six elderly oral aminophylline steady-state and ciprofloxacin 3d after steady-state, before and after theophylline combination of plasma concentrations and adverse reactions are synchronized Observed, PKBP-N1 package according to a one-compartment model of the data processing and statistical analysis of the results, ciprofloxacin so that the elimination half-life of theophylline significantly (P <0.05), resulting in significant blood concentration (P <0.05), but had no significant effect on the distribution volume and clearance rate (P> 0.05). Two drugs during the combination of theophylline side effects. The results suggest that: ciprofloxacin inhibit the normal metabolism of theophylline, the two combined, should consider reducing the amount of theophylline.