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目的:分析我院药品不良反应/事件(ADR/ADE)发生的特点、一般规律和引发的相关因素,促进临床合理用药。方法:对我院2009年收集上报的208例ADR/ADE报告进行回顾性分析。结果:208例ADR/ADE涉及78种药品,其中抗微生物药居首(70.67%),其次是中药制剂(14.90%);0～10岁患者所占比例最高(26.92%);静滴是引起ADR/ADE的主要途径(86.69%);临床表现以皮肤及附件损害最常见(42.00%);新的严重的不良反应21例;对症治疗的92例,未进行特殊处理的116例。结论:应进一步加强ADR/ADE的监测,合理规范使用药物。静脉给药方式及抗微生物药、中药制剂的应用是ADR/ADE发生的主要因素,应加强监督管理。
OBJECTIVE: To analyze the characteristics, general rules and related factors of adverse drug reactions (ADR / ADE) in our hospital so as to promote clinical rational use of drugs. Methods: A retrospective analysis of 208 ADR / ADE reports collected in our hospital in 2009 was conducted. Results: A total of 208 ADR / ADEs were involved in the study, of which 78 were antimicrobials (70.67%) followed by TCM preparations (14.90%). The highest proportion of patients aged 0-10 years (26.92%) was caused by intravenous drip ADR / ADE (86.69%). The most common clinical manifestations were skin and accessory lesions (42.00%), 21 new serious adverse reactions, 92 symptomatic treatments and 116 untreated cases. Conclusion: The monitoring of ADR / ADE should be further strengthened and drugs should be properly regulated. Intravenous administration and antimicrobial drugs, the application of traditional Chinese medicine is the main factor in the occurrence of ADR / ADE, should strengthen supervision and management.