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以克山病病区和非病区粮饲养大鼠(饲料号为13和35)6—13周进行~(75)Se示踪代谢实验,观察11种组织脏器(褐脂、胸腺、血液、心脏、肺、肌肉、骨、肾、脾、肝、肠)~(75)Se(Na_2SeO_3)的吸收量和体内分布状况。结果表明,自由进食条件下,病区饲料组动物~(75)Se吸收量高于非病饲料组。其中以13号莜麦饲料组差异最为明显(A实验)。对饲条件下病区组动物~(75)Se的吸收量仍高于非病区组。但是差异程度较自由进食组为小(B实验)。各组动物体内不同组织脏器~(75)Se的分布梯度呈现一定规律性。皆以肾脏的吸收量为最高,其次是肝、脾脏及胸腺等,吸收量最低的是肌肉、心脏及骨骼。 在观察的一周之内,随时间的增加,~(75)Se于组织脏器中的含量,病区饲料组与非病区饲料组有不同的动态变化。 病区与非病区组间~(75)Se吸收量规律性差别,反映了病区组动物在病区出产的饲料影响下,体内硒不足或缺乏,表明病区与非病区出产的粮食存在着质的差异,证实了病区水土——食物链因素对动物机体硒代谢有明显影响。
Keshan disease and non-ward feeding rats (feed no. 13 and 35) for 6-13 weeks were subjected to ~ (75) Se tracer metabolism test to observe the changes of 11 kinds of tissues (brown fat, thymus, blood , Heart, lung, muscle, bone, kidney, spleen, liver, intestine) ~ (75) Se (Na_2SeO_3) and its distribution in vivo. The results showed that under the condition of free feeding, the absorption of ~ (75) Se in the feed of the ward was higher than that of the non-sick feed. Among them, the difference was notable in No. 13 oat feed group (A experiment). Absorption of ~ (75) Se in the ward group was still higher than that in the non-ward group. However, the difference was significantly lower than that of the free-eating group (B experiment). The distribution gradient of ~ (75) Se in different tissues of different groups showed certain regularity. Kidney absorption is the highest, followed by the liver, spleen and thymus, etc., the lowest absorption of muscle, heart and bone. Within one week of observation, the content of ~ (75) Se in the tissues and organs of the diseased area and the non-diseased area changed dynamically with the increase of time. The regularity of absorption of ~ (75) Se between the ward and the non-ward was reflected in the lack of selenium or lack of selenium in the ward under the influence of the feed produced in the ward, indicating that the ward There is a qualitative difference, confirming the ward soil and water - food chain factors have a significant impact on animal selenium metabolism.