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目的:观察宫颈环形电切除术(LEEP)后采用保妇康栓治疗人乳头瘤病毒(HPV)阳性宫颈糜烂的疗效。方法:168例HPV阳性宫颈糜烂患者分为观察组和对照组。两组患者均行LEEP术治疗,术后常规予重组人干扰素α2a注射液300万IU,im qd。对照组术后1个月后予复方沙棘籽油栓2.7 g qd阴道给药,观察组术后1个月后予保妇康栓3.48 g qd阴道给药。疗程均为2周。观察两组患者各项症状改善情况,HPV DNA负荷量及转阴率,比较两组疗效。结果:治疗后,两组患者白带异常、腰骶疼痛、下腹胀痛及接触性出血等临床症状均得到明显改善(P<0.01),且观察组症状改善状况明显优于对照组(P<0.01)。两组患者的HPV DNA负荷量均明显降低(P<0.01),且观察组治疗后负荷量明显低于对照组(P<0.01),HPV转阴率明显高于对照组(P<0.01)。观察组总有效率(95.45%)明显高于对照组(P<0.01)。结论:LEEP后采用保妇康栓治疗HPV阳性宫颈糜烂疗效显著,能明显改善患者各项症状,降低HPV DNA负荷量,提高HPV转阴率。
Objective: To observe the curative effect of Baofukang suppository on HPV-positive cervical erosion after cervical ring electrosurgical excision (LEEP). Methods: 168 cases of HPV-positive cervical erosion patients were divided into observation group and control group. Two groups of patients underwent LEEP surgery, postoperative conventional recombinant human interferon α2a injection 3000000 IU, im qd. One month after operation, the control group received intragastric administration of 2.7 g qd of seabuckthorn seed oil suppository and vaginal administration of Baofukang suppository (3.48 g qd) one month after operation. The course of treatment is 2 weeks. To observe the two groups of patients to improve the symptoms, HPV DNA load and negative rate, the two groups were compared. Results: After treatment, clinical symptoms such as vaginal discharge, lumbosacral pain, abdominal pain and contact bleeding were significantly improved in both groups (P <0.01), and the symptom improvement in the observation group was significantly better than that in the control group (P <0.01) ). The load of HPV DNA in both groups were significantly decreased (P <0.01), and the load of the observation group was significantly lower than that of the control group (P <0.01). The negative rate of HPV was significantly higher than that of the control group (P <0.01). The total effective rate in the observation group (95.45%) was significantly higher than that in the control group (P <0.01). Conclusions: The treatment of HPV-positive cervical erosion after LEEP is effective in treating HPV-positive cervical erosion. It can significantly improve the symptoms of patients, reduce the load of HPV DNA and increase the negative rate of HPV.