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目的:观察醒脑静注射液联合头孢曲松治疗化脓性脑膜炎患儿的疗效。方法:100例化脓性脑膜炎患儿随机分为对照组50例和观察组50例,对照组予常规治疗;观察组在对照组基础上加用醒脑静注射液0.4~0.6ml·kg-1·d-1。两组疗程均为3 d。比较两组体温正常、外周血及脑脊液WBC计数正常时间与住院时间,以及两组患儿治疗前后血及脑脊液中肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平变化,评价两组临床疗效,比较并发症及随访6个月后的后遗症发生情况。结果:与对照组相比,观察组体温正常时间和脑脊液WBC计数正常时间均明显缩短(P<0.05),血清及脑脊液TNF-α含量下降更显著(P<0.05),观察组临床总有效率明显高于对照组(P<0.05)。其余指标两组比较差异无统计学意义(P>0.05)。结论:醒脑静注射液辅助治疗化脓性脑膜炎能有效改善患儿症状,纠正炎症因子异常,临床疗效高,值得临床推广。
Objective: To observe the effect of Xingnaojing injection combined with ceftriaxone on children with purulent meningitis. Methods: One hundred children with purulent meningitis were randomly divided into control group (n = 50) and observation group (n = 50). The control group was given routine treatment. The observation group was treated with xingnaojing injection 0.4 ~ 0.6ml · kg- 1 · d-1. The two courses of treatment were 3 d. The normal and peripheral blood and cerebrospinal fluid counts of WBC were compared between the two groups before and after treatment, and the levels of tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in blood and cerebrospinal fluid Two groups of clinical efficacy, complication and complications after 6 months of sequelae. Results: Compared with the control group, the normal temperature of the observation group and the normal time of cerebrospinal fluid WBC count were significantly shortened (P <0.05), the serum and cerebrospinal fluid TNF-α levels decreased more significantly (P <0.05) Significantly higher than the control group (P <0.05). The remaining indicators of two groups showed no significant difference (P> 0.05). Conclusion: Xingnaojing injection adjuvant treatment of purulent meningitis can effectively improve the symptoms of children, to correct the abnormalities of inflammatory cytokines, high clinical efficacy, it is worth clinical promotion.