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为研究 I型纤溶酶原激活物抑制物 (PAI- 1)在紫癜肾炎病理机制中的作用。采用免疫组织化学和原位杂交方法检测了 2 3例紫癜肾炎患者肾组织中的 PAI- 1。结果证实 :在正常肾组织内和紫癜肾炎肾组织内均可检测到 PAI- 1表达 ,PAI-1m RNA原位杂交阳性信号主要分布于血管平滑肌细胞和肾小管上皮细胞内 ,紫癜肾炎肾小球内有紫兰色阳性信号 ,且强度与肾小球内细胞的增生程度有关
To investigate the role of type I plasminogen activator inhibitor (PAI-1) in the pathology of purpura nephritis. PAI-1 in renal tissues from 23 patients with purpura nephritis was detected by immunohistochemistry and in situ hybridization. The results confirmed that PAI-1 expression was detectable both in normal kidney tissues and in purpura nephritis kidney tissues. Positive signals of PAI-1m RNA in situ hybridization were mainly distributed in vascular smooth muscle cells and renal tubular epithelial cells. Purpura nephritis glomerulus There are purple positive signals, and the intensity and glomerular cells within the degree of proliferation