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本文对30例胃腺癌病人的手术前后血液和不同区域胃组织中的胃泌素(GAS)、胰高血糖素(GLU)和胰岛素(INS)含量进行测定,结果显示,癌中心、癌旁及淋巴结(转移)等有癌细胞存在的组织中GAS含量明显高于无癌组织及血液,组间差异显著(P<0.01)。有癌细胞存在的组织间含量无明显差异;胃癌病人组织和血液中的GLU的含量均明显升高,有癌组织尤为明显。与术后血液间比较差异显著(P<0.05)。不同区域胃癌的各组织和血液中的GAS、GLU、INS含量均无统计学意义,研究认为,人胃癌细胞能分泌GAS、促GAS释放肽和GLU及GLU样肽类物质,并可作用于癌细胞上的相应受体进行自分泌调节,这种自分泌功能与胃癌所在区域无关,具有一定的独立性,这可能是导致肿瘤恶性膨胀的因素之一。术前检测血液中的GAS、GLU和INS等可以作为推测胃癌有无淋巴转移和了解胃的病理状态的一项参考指标。
In this paper, gastrin (GAS), glucagon (GLU), and insulin (INS) levels in blood and gastric tissues from 30 patients with gastric adenocarcinoma before and after surgery were measured. The results showed that the cancer center, adjacent cancer and lymph nodes The GAS content in tissues with cancerous cells such as metastasis was significantly higher than that in non-cancer tissues and blood, with significant differences between groups (P<0.01). There was no significant difference in the presence of cancerous tissue between tissues; the GLU content in tissues and blood of patients with gastric cancer was significantly increased, especially in cancerous tissues. There was a significant difference from postoperative blood (P<0.05). The GAS, GLU, and INS levels in gastric cancer tissues and blood in different regions were not statistically significant. It was considered that human gastric cancer cells can secrete GAS, promote GAS release peptides, GLU and GLU-like peptides, and can act on cancers. The corresponding receptors on the cells undergo autocrine regulation. This autocrine function is independent of the region of gastric cancer and has certain independence. This may be one of the factors leading to malignant expansion of the tumor. Preoperative detection of GAS, GLU and INS in the blood can be used as a reference indicator to predict the presence of lymph node metastasis in gastric cancer and to understand the pathological state of the stomach.