Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer

• 作 者: Kazuyuki Matsushita Hideaki Sh
• 机 构: DepartmentofMolecularDiagnosisGraduateSchoolofMedicineChibaUniversityChiba260-8670Japan,Departmentof
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年15期
• 关键词: Cancer gene therapy C-MYC SUPPRESSOR FAR up STREAM Cancer gene therapy c-myc su
• 基金项目: In part by the 21st Century COE(Center Of Ex-cellence)Programs to Dr.Takenori Ochiai,by a Grant-in-Aid 18591453 to K.M from the Ministry of Education,Science,Sports and Culture of Japan

AIM:To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element(FUSE)-binding protein-interacting repressor(FIR).METHODS:Endogenous c-Myc suppression and apoptosis induction by a transient FIR-expr