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目的 研究 Ｃ Ｄ４４ 粘附分子在颅内转移瘤及脑胶质母细胞瘤中的表达情况及其与这些肿瘤发生侵袭、转移的关系。方法 用抗 Ｃ Ｄ４４ 正常型（ Ｃ Ｄ４４ｓ） 蛋白单克隆抗体及抗 Ｃ Ｄ４４ 变体型（ Ｃ Ｄ４４ｖ３１０） 蛋白多克隆抗体免疫组化染色检测１０ 例正常脑组织、２０ 例脑胶质母细胞瘤和２０ 例颅内转移瘤中 Ｃ Ｄ４４ 粘附分子的表达情况。结果 １０ 例正常脑组织中 Ｃ Ｄ４４ｓ 和 Ｃ Ｄ４４ｖ３１０ 表达均阴性；２０ 例脑胶质母细胞瘤 Ｃ Ｄ４４ｓ 阳性表达率为１００ ％ ， Ｃ Ｄ４４ｖ３１０ 表达阴性；２０ 例颅内转移瘤 Ｃ Ｄ４４ｓ 表达阳性率为９０ ％ ， Ｃ Ｄ４４ｖ３１０ 表达阳性率为７０ ％ 。 Ｃ Ｄ４４ｖ３１０ 在颅内转移瘤及脑胶质母细胞瘤的表达差异有显著性（ Ｐ＜ ０ ．０１） 。结论 脑胶质母细胞瘤中 Ｃ Ｄ４４ｓ 的表达可能与其脑内侵袭过程有关，无 Ｃ Ｄ４４ｖ 表达可能与其很少发生颅外转移有关； Ｃ Ｄ４４ｖ 可能在颅内转移瘤向颅内转移的过程中起重要作用，且有可能成为颅内转移瘤诊治的有用指标之一。
Objective To study the expression of C D44 adhesion molecules in intracranial metastases and brain glioblastoma and its relationship with invasion and metastasis of these tumors. Methods Immunohistochemical staining with polyclonal anti-C D44s monoclonal antibody and anti-C D44v310 protein was used to detect the expression levels of 10 normal brain tissues, 20 glioblastoma And 20 cases of intracranial metastases C D44 adhesion molecule expression. Results 10 cases of normal brain tissue C D44s and C D44v3 10 expression were negative; 20 cases of glioblastoma C D44s positive expression rate was 100%, C D44v3 10 expression was negative; 20 cases of intracranial metastases C D44s The positive rate was 90%, the positive rate of C D44v310 expression was 70%. C D44v3 10 in intracranial metastases and glioblastoma expression was significantly different (P <0 .01). Conclusions The expression of C D44s in brain glioblastoma may be related to the process of invasion in brain, and the expression of C D44v may be related to its less occurrence of extracranial metastasis. C D44v may play a role in intracranial metastasis of intracranial metastases And it may become one of the useful indicators for diagnosis and treatment of intracranial metastases.