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目的探讨胃癌浸润与细胞增殖和细胞凋亡标记程度的相关性。方法外科手术切除的50例胃癌均经病理对浸润深度进行确认。病变粘膜用增殖细胞核抗原（PCNA）标记和DNA原位末端标记（TUNEL）进行检测。结果胃癌组织PCNA阳性细胞标记指数为（0.69±0．20），TUNEL总标记指数为（137±3．2）。低分化胃癌TUNEL标记指数明显降低。PCNA标记与胃癌浸润程度呈正相关，TUNEL呈逆相关改变。结论PCNA及TUNEL标记与胃癌浸润程度及淋巴结转移状态有明显的相关性，细胞增殖与凋亡的异常改变可能是胃癌浸润转移的机制之一。
Objective To investigate the correlation between gastric cancer infiltration and cell proliferation and apoptosis markers. Methods The surgical resection of 50 cases of gastric cancer were confirmed by pathological depth of invasion. Lesions of the mucosa with proliferating cell nuclear antigen (PCNA) markers and DNA in situ end-labeling (TUNEL) were detected. Results The index of PCNA positive cells in gastric cancer was (0.69 ± 0.20) and the total labeling index of TUNEL was (137 ± 3.2). Poorly differentiated gastric cancer TUNEL labeling index was significantly lower. PCNA labeling was positively correlated with the degree of gastric cancer infiltration, TUNEL was inversely correlated. Conclusions The expressions of PCNA and TUNEL were significantly correlated with the infiltration of gastric cancer and lymph node metastasis. The abnormal changes of cell proliferation and apoptosis may be one of the mechanisms of gastric cancer invasion and metastasis.