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目的探讨脑出血患者氧化与抗氧化系统功能状况及其临床意义。方法检测１３３例脑出血患者和１００例健康对照者血浆一氧化氮（Ｐ－ＮＯ）含量、血浆维生素Ｃ（Ｐ－ＶＣ）含量、血浆维生素Ｅ（Ｐ－ＶＥ）含量、血浆过氧化脂质（Ｐ－ＬＰＯ）含量、血浆超氧化物歧化酶（Ｐ－ＳＯＤ）活性、红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）活性、红细胞过氧化脂质（Ｅ－ＬＰＯ）含量。结果与对照组比较，患者组的Ｐ－ＮＯ、Ｐ－ＬＰＯ、Ｅ－ＬＰＯ平均值均显著升高（Ｐ＜０．００１），Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－ＳＯＤ、Ｅ－ＳＯＤ平均值均显著降低（Ｐ＜０．００１），逐步回归分析发现，患者临床神经功能缺失程度积分与Ｐ－ＮＯ、Ｐ－ＶＣ、Ｅ－ＬＰＯ值相关最为密切，而颅内血肿量却与Ｐ－ＮＯ、Ｐ－ＶＥ、Ｅ－ＬＰＯ值相关最为密切。结论脑出血患者体内氧化抗氧化平衡严重失调，且这一病理改变在脑出血后继发性脑损害的形成过程中起着重要的作用。
Objective To investigate the functional status of oxidation and anti-oxidation system in patients with cerebral hemorrhage and its clinical significance. Methods The levels of plasma nitric oxide (P-NO), plasma vitamin C (P-VC) and plasma vitamin E (P-VE) were measured in 133 cerebral hemorrhage patients and 100 healthy controls. Plasma lipid peroxidation P-LPO), plasma superoxide dismutase (P-SOD) activity, erythrocyte superoxide dismutase (E-SOD) activity and erythrocyte peroxidation lipid (E-LPO) Results Compared with the control group, the average values of P-NO, P-LPO and E-LPO in patients were significantly increased (P <0.001), and the mean of P-VC, P-VE, P-SOD and E-SOD (P <0.001). The stepwise regression analysis showed that the scores of clinical neurological deficit were the most closely related to the values of P-NO, P-VC and E-LPO, while the intracranial hematoma was significantly correlated with P- NO, P-VE, E-LPO values most closely. Conclusion The balance of oxidation and antioxidation in patients with intracerebral hemorrhage is seriously imbalanced, and this pathological change plays an important role in the formation of secondary brain damage after intracerebral hemorrhage.