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目的分析原发性胃淋巴瘤(primary gastric lymphoma,PGL)预后与临床病理因素及治疗方式的关系。方法随访我院1991年5月~2006年12月44例接受手术治疗的PGL患者,用Kaplan-Meier生存分析、COX多因素分析研究预后与临床病理因素以及治疗方式的关系。结果手术切除率为88.64%,根治性切除率为79.55%。33例接受化疗,死亡1例。40例随访6月~15年,3年存活率为85.00%,5年存活率为67.24%。手术+化疗患者3年存活率为86.35%,5年存活率为82.43%。细胞分级、周围器官或远处转移、手术方式、术后是否化疗是PGL的独立预后因素,其它临床病理因素不能作为独立预后因素。结论PGL的治疗应以手术、化疗为主,化疗可能更为重要,联合应用可以获得满意效果。细胞分级、周围器官或远处转移、手术方式、术后是否化疗可以预测其预后。
Objective To analyze the relationship between the prognosis of primary gastric lymphoma (PGL) and clinical and pathological factors and treatment modalities. METHODS: Forty-four patients with PGL who underwent surgical treatment from May 1991 to December 2006 in our hospital were followed up. Kaplan-Meier survival analysis and multivariate COX analysis were used to investigate the relationship between prognosis and clinicopathologic factors and treatment modalities. Results The surgical resection rate was 88.64% and the radical resection rate was 79.55%. 33 cases received chemotherapy, 1 patient died. 40 cases were followed up for 6 months to 15 years. The 3-year survival rate was 85.00% and the 5-year survival rate was 67.24%. Surgical + chemotherapy patients 3-year survival rate was 86.35%, 5-year survival rate was 82.43%. Cell classification, peripheral organs or distant metastases, surgical procedures, postoperative chemotherapy is an independent prognostic factor for PGL, other clinical and pathological factors can not be used as an independent prognostic factor. Conclusion The treatment of PGL should be based on surgery and chemotherapy. Chemotherapy may be more important and the combined application can achieve satisfactory results. Cell classification, peripheral organs or distant metastases, surgical methods, postoperative chemotherapy can predict the prognosis.