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目的 :探讨咪唑安定清醒镇静用于胃镜检查所需的剂量与年龄、性别的相关性 ,并观察其镇静效果及对呼吸循环的影响。方法 :2 10例胃镜检查患者 ,先给予咪唑安定 0 .0 2mg/kg,以后追加 0 .0 1mg/kg至OAA/S评分达 3分止。记录所需咪唑定安剂量 ,并记录检查过程中MAP ,HR ,SpO2 和BIS的变化及检查后患者的遗忘度、满意度。结果 :咪唑安定用于胃镜检查是安全有效的 ,其所需剂量与年龄呈明显负相关 (男性γ =- 0 .784,女性γ =- 0 .76 2 ,P <0 .0 1) ,而与性别无相关性。结论 :咪唑安定清醒镇静用于胃镜检查所需剂量与年龄成负相关。
OBJECTIVE: To investigate the correlation between the dosage of midazolam for conscious sedation and age and sex required for gastroscopy, and to observe its sedation and its effects on the respiratory cycle. Methods: Twenty patients with gastroscopy were given midazolam 0.2 02 mg / kg, and then added 0. 01 mg / kg until the OAA / S score reached 3 points. Record the required dose of imidazole, and record the change of MAP, HR, SpO2 and BIS and the degree of amnesia and satisfaction of the patients after the examination. Results: Midazolam was safe and effective for gastroscopy. The required dose was negatively correlated with age (γ = - 0.784 for males and = 0.762 for females, P <0.01), while No gender relatedness. CONCLUSIONS: The dose of midazolam conscious sedation required for gastroscopy is inversely related to age.