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目的 观察联合使用环氧化酶抑制剂阿斯匹林 (Asp)和组织胺H2受体阻滞剂西米替丁 (Cim)对腹腔感染大鼠全肠外营养 (TPN )时蛋白质分解的调理作用。方法 采用 2 8只成年腹腔感染大鼠 ,随机分成对照组 (TPN组 )和实验组 (Asp +Cim组 )。对照组给予常规TPN ,实验组在TPN溶液中加入注射用赖氨匹林 15mg/kg·d-1和西米替丁注射液每天 80mg/kg体重 ,实验持续 4d。测定实验前后体重、血清总蛋白、白蛋白、尿素氮和肌苷的浓度 ;测定每日氮平衡和尿 3 甲基组氨酸 (3 MH)的排出量 ,计算累积氮平衡和累积尿 3 甲基组氨酸排出量。结果 实验组血清学指标实验前后变化的差值比对照组显著减少 ;累积氮平衡显著优于对照组 (P <0 .0 1) ;累积尿 3 甲基组氨酸排出量比对照组显著减少 (P <0 .0 1)。结论 环氧化酶抑制剂阿斯匹林 (Asp)联合组织胺H2受体阻滞剂西米替丁 (Cim )可以调理腹腔感染大鼠全肠外营养 (TPN)时的蛋白质代谢 ,减少蛋白质丢失。
Objective To investigate the effect of combined use of cyclooxygenase inhibitor aspirin (Hyp) and histamine H2 receptor blocker cimidine (Cim) on protein breakdown during peritoneal inoculation of total parenteral nutrition (TPN) effect. Methods Twenty-eight adult infertile rats were randomly divided into control group (TPN group) and experimental group (Asp + Cim group). The control group was given conventional TPN. The experimental group was treated with 15 mg / kg · d-1 of aspirin for injection and 80 mg / kg of body weight of cimetidine injection daily in TPN solution for 4 days. The body weight, serum total protein, albumin, urea nitrogen and inosine concentrations were measured before and after the experiment. The daily nitrogen balance and urinary 3-methyl-histidine (3 MH) levels were measured to calculate the cumulative nitrogen balance Histidine output. Results The differences of serum indexes before and after the experiment in experimental group were significantly lower than those in control group. The cumulative nitrogen balance was significantly better than that in control group (P <0.01). The cumulative urine 3-methyl-histidine significantly decreased (P <0. 01). CONCLUSIONS: Cyclooxygenase inhibitor aspirin combined with histamine H2 receptor blocker cimidine can modulate protein metabolism in rats with peritoneal infection of total parenteral nutrition (TPN) and reduce protein Lost