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本文报告了哌仑西平和阿托品的药理实验结果。1.哌仑西平和阿托品对大鼠的幽门结扎、冷水应激和利血平诱导的胃溃疡均有预防作用。2.两化合物在大鼠胃肠蠕动实验中有重要差别。哌仑西平的抑制作用弱于阿托品。3.关于毛果芸香碱刺激兔的唾液分泌,哌仑西平的抑制率明显的低于阿托品。4.兔的瞳孔直径测量表明:阿托品的扩瞳效应比哌仑西平强得多,且有效期也比哌仑西平长。
This article reports the results of pharmacological experiments of pirenzepine and atropine. Pirenzepine and atropine have preventive effects on pylorus ligation, cold water stress and reserpine-induced gastric ulcer in rats. 2. The two compounds in rat gastrointestinal motility test have important differences. Pirenzepine is less potent than atropine. 3 on pilocarpine stimulation of saliva secretion in rabbits, pirenzepine inhibition rate was significantly lower than atropine. The measurement of pupil diameter of rabbit shows that the atropine has a much stronger pupil dilation effect than pirenzepine and has a longer duration of action than pirenzepine.