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抗痫药物对认知和学习的影响在过去10年逐渐引起重视.研究表明,抗惊厥药在多药治疗和/或使用过量均可对精神运动性操作产生有害影响.本文旨在评价学龄儿童长期用苯巴比妥(PB)或丙戊酸(VPA)治疗对学习能力的影响.研究了64例癫痫患儿(32例服PB,32例服VPA)及60名年龄相匹配的正常对照组.治疗均单一用药,至少6个月以上,且血药浓度在治疗范围内(均不
The impact of antiepileptic drugs on cognition and learning has drawn increasing attention over the past decade and studies have shown that anticonvulsants can have detrimental effects on psychomotor performance in multidrug therapies and / or overdoses. This article aims to evaluate the effects of anticonvulsants on school-aged children Long-term effects of phenobarbital (PB) or valproic acid (VPA) on learning ability were studied in 64 children with epilepsy (32 with PB and 32 with VPA) and 60 age-matched normal controls Group were treated with a single medication, at least 6 months or more, and plasma concentration within the treatment range (none