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为了发展有效的恙虫病疫苗,首先要了解人类保护性免疫的性质。作者于1976～1977年在澎湖列岛用间接微免疫荧光抗体试验检测108例男性军人病者的特异性 IgM 与IgG 抗体反应,还研究其中部分患者的一些非抗原特异性细胞反应情况。本组病例均具典型体征与症状(包括发热、焦痂与头痛),并可分离出恙虫病立克次体。发现两种不同类型的抗立克次体抗体反应,78例呈Ⅰ型反应,即初期反应,多半发生于发病4～8天,其余在8天时血清出现特异性 IgM 抗体,而且
In order to develop an effective scrub typhus vaccine, we must first understand the nature of human protective immunity. In 1976 ~ 1977 in Penghu Islands indirect immunofluorescence antibody test detected 108 cases of male military patients with specific IgM and IgG antibody response, but also some of the patients in some non-antigen-specific cellular response. This group of patients with typical signs and symptoms (including fever, eschar and headache), and the scrub typhus Rickettsia can be isolated. Two different types of anti-rickettsial antibody responses were found, 78 were type I responses, ie, initial responses, most of which occurred between 4 and 8 days of onset and the rest of the sera appeared specific serum IgM antibodies at day 8, and