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目的探究醋酸戈舍瑞林缓释植入剂(诺雷德)联合米非司酮预防子宫内膜异位症术后复发的疗效。方法 56例行子宫内膜异位症手术患者,依据治疗方法不同分为研究组与对照组,各28例。对照组予以诺雷德治疗,研究组采用诺雷德联合米非司酮治疗。观察记录两组患者临床效果、疾病复发率、不良反应发生情况及治疗后妊娠率。结果研究组临床总有效率为92.86%,疾病复发率为7.14%,对照组总有效率为71.43%,疾病复发率为28.57%。比较差异均有统计学意义(P<0.05)。研究组不良反应发生率为42.86%(12/28),1年后妊娠受孕率为82.14%(23/28),均优于对照组的78.57%、39.29%,差异有统计学意义(P<0.05)。结论诺雷德与米非司酮联合预防、治疗子宫内膜异位症术后复发,效果颇佳,可有效提高妊娠几率,降低复发率及不良反应发生率,在临床治疗中具有重要意义。
Objective To investigate the curative effect of Goserelin acetate sustained-release implants (Norelde) in combination with mifepristone in the prevention of postoperative recurrence of endometriosis. Methods Fifty-six patients with endometriosis were divided into study group and control group according to the different treatment methods, 28 cases in each group. The control group was treated with Noreid, and the study group was treated with Noreide and mifepristone. The clinical efficacy, recurrence rate, incidence of adverse reactions and pregnancy rate after treatment were recorded and recorded. Results The total effective rate of the study group was 92.86%, the disease recurrence rate was 7.14%, the total effective rate of the control group was 71.43%, the disease recurrence rate was 28.57%. The differences were statistically significant (P <0.05). The incidence of adverse reactions in the study group was 42.86% (12/28). Pregnancy conception rate after one year was 82.14% (23/28), which was significantly better than that of the control group (78.57%, 39.29%, P < 0.05). Conclusion Noreide and mifepristone combined with prophylaxis and treatment of postoperative recurrence of endometriosis, the effect is quite good, which can effectively improve the probability of pregnancy, reduce the recurrence rate and the incidence of adverse reactions in the clinical treatment of great significance.