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目的观察丹红注射液联合缬沙坦对早期糖尿病肾病患者实施治疗的临床效果。方法 102例早期糖尿病肾病患者,随机分为观察组与对照组,每组51例。观察组患者使用丹红注射液联合缬沙坦实施治疗,对照组患者单纯使用缬沙坦实施治疗,对比两组患者的临床治疗效果。结果治疗后,观察组患者全血低切粘度、红细胞压积、纤维蛋白原以及全血高切粘度等均比治疗前降低(P<0.05);而对照组患者与治疗前比较降低不明显,差异无统计学意义(P>0.05);治疗后观察组患者全血低切粘度、红细胞压积、纤维蛋白原以及全血高切粘度均优于对照组,差异有统计学意义(P<0.05)。治疗后观察组尿蛋白排泄率(UAER)为(48.2±9.5)μg/min,尿β2-微球蛋白(β2-MG)为(14.1±7.0)mmol/L,均优于对照组的(74.1±10.3)μg/min、(16.8±8.9)mmol/L,差异具有统计学意义(P<0.05)。结论使用丹红注射液联合缬沙坦对早期糖尿病肾病患者实施治疗临床效果较好,可以在临床中推广使用。
Objective To observe the clinical effect of Danhong injection combined with valsartan in the treatment of patients with early diabetic nephropathy. Methods A total of 102 patients with early diabetic nephropathy were randomly divided into observation group and control group, with 51 cases in each group. Patients in the observation group were treated with Danhong injection combined with valsartan. Patients in the control group were treated with valsartan alone, and the clinical effects were compared between the two groups. Results After treatment, the low-cut whole blood viscosity, hematocrit, fibrinogen and whole blood high shear viscosity of the observation group were lower than those before treatment (P <0.05), while those of the control group were not significantly lower than those before treatment There was no significant difference between the two groups (P> 0.05). After treatment, the whole blood low shear viscosity, hematocrit, fibrinogen and whole blood high shear viscosity of the observation group were better than those of the control group (P <0.05) ). The urinary protein excretion rate (UAER) was (48.2 ± 9.5) μg / min and the urinary β2-microglobulin (β2-MG) was (14.1 ± 7.0) mmol / L in the observation group after treatment, ± 10.3) μg / min and (16.8 ± 8.9) mmol / L, respectively. The difference was statistically significant (P <0.05). Conclusion Danhong injection combined with valsartan for early diabetic nephropathy in patients with clinical treatment is better, it can be used in clinical practice.