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丙戊酸钠 (sodium valproate,SVPA)为临床常用广谱抗癫药物 ,因其丙戊酸 (valproate acid,VPA)治疗血药浓度范围窄 (50～ 1 0 0︼g/ml) ,需进行常规的治疗血药浓度监测 (TDM) [1～ 3] 。我院自1 995年至今共有 50 0多人次的 VPA血药浓度监测 ,均为当天取样当天测定。在常规 T
Sodium valproate (SVPA) is a commonly used broad-spectrum antiepileptic drug in clinical practice. Its plasma concentration range is narrow (50 ~ 100 μg / ml) due to valproate acid (VPA) Routine treatment of plasma concentration monitoring (TDM) [1 ~ 3]. Our hospital since1995 so far a total of more than 50 people VPA plasma concentration monitoring, were measured on the day of sampling. In conventional T