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AIM To investigate whether the preoperative neutrophil-tolymphocyte ratio(NLR) could predict the prognosis of hepatocellular carcinoma(HCC) patients with portal/hepatic vein tumor thrombosis(PVTT/HVTT) after hepatectomy.METHODS The study population included 81 HCC patients who underwent hepatectomy and were diagnosed with PVTT/HVTT based on pathological examination. The demographics, laboratory analyses, and histopathology data were analyzed.RESULTS Overall survival(OS) and disease-free survival(DFS) were determined in the patients with a high(> 2.9) and low(≤ 2.9) NLR. The median OS and DFS duration in the high NLR group were significantly shorter than those in the low NLR group(OS: 6.2 mo vs 15.7 mo, respectively, P = 0.007; DFS: 2.2 mo vs 3.7 mo, respectively, P = 0.039). An NLR > 2.9 was identified as an independent predictor of a poor prognosis of OS(P = 0.034, HR = 1.866; 95%CI: 1.048-3.322) in uni-and multivariate analyses. Moreover, there was a significantly positive correlation between the NLR and the Child-Pugh score(r = 0.276, P = 0.015) and the maximum diameter of the tumor(r = 0.435, P < 0.001). Additionally, the NLR could enhance the prognostic predictive power of the CLIP score for DFS in these patients. CONCLUSION The preoperative NLR is a prognostic predictor after hepatectomy for HCC patients with PVTT/HVTT. NLR > 2.9 indicates poorer OS and DFS.
AIM To investigate whether the preoperative neutrophil-tolymphocyte ratio (NLR) could predict the prognosis of hepatocellular carcinoma (HCC) patients with portal / hepatic vein tumor thrombosis (PVTT / HVTT) after hepatectomy. METHODS The study population included 81 HCC patients who underwent hepatectomy and were diagnosed with PVTT / HVTT based on pathological examination. The demographics, laboratory analyzes, and histopathology data were analyzed .RESULTS Overall survival (OS) and disease-free survival (DFS) were determined in the patients with a high (> 2.9) The median OS and DFS duration in the high NLR group were significantly shorter than those in the low NLR group (OS: 6.2 mo vs 15.7 mo, respectively, P = 0.007; DFS: 2.2 mo vs 3.7 An NLR> 2.9 was identified as an independent predictor of a poor prognosis of OS (P = 0.034, HR = 1.866; 95% CI: 1.048-3.322) in uni-and multivariate analyzes. there was a significant positive correlat The NLR could enhance the prognostic predictive power of the CLIP score (r = 0.276, P = 0.015) and the maximum diameter of the tumor (r = 0.435, P <0.001) for DFS in these patients. CONCLUSION The preoperative NLR is a prognostic predictor after hepatectomy for HCC patients with PVTT / HVTT. NLR> 2.9 indicates poorer OS and DFS.