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目的:探讨血清血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(b-FGF)在儿童烟雾病发病中的作用。方法:采用双抗体酶联免疫吸附法(ELISA)检测42例烟雾病患儿和40例健康儿童血清VEGF及b-FGF水平。结果:烟雾病患儿血清VEGF和b-FGF水平明显高于健康儿童,两组比较差异均有统计学意义(P<0.01);出血型烟雾病患儿血清VEGF和b-FGF水平明显高于缺血型(P<0.05);Suzuki级别与VEGF和b-FGF水平呈正相关(P<0.01);血清VEGF与b-FGF水平呈正相关(P<0.01)。结论:VEGF和b-FGF与烟雾病新生血管的发生有密切关系,血清VEGF及b-FGF水平可一定程度上反映烟雾病患儿的血管病变程度。
Objective: To investigate the role of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) in the pathogenesis of moyamoya disease in children. Methods: Serum levels of VEGF and b-FGF were measured in 42 children with moyamoya disease and 40 healthy children by double antibody enzyme-linked immunosorbent assay (ELISA). Results: The levels of serum VEGF and b-FGF in children with moyamoya disease were significantly higher than those in healthy children (P <0.01). The levels of serum VEGF and b-FGF in children with moyamoya disease were significantly higher than those in healthy children (P <0.05). There was a positive correlation between the levels of VEGF and b-FGF and the levels of serum VEGF and b-FGF (P <0.01). Conclusion: VEGF and b-FGF are closely related to the occurrence of neovascular moyamoya disease. The levels of serum VEGF and b-FGF may reflect the extent of vascular lesions in children with moyamoya disease.