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目的:观察布地奈德氧气驱动雾化吸入对新生儿呼吸窘迫综合征(NRDS)呼吸困难症状改善时间及吸氧时间的影响并评价疗效。方法:选取2011年6月至2013年6月在我院产科出生的NRDS早产儿98例,随机分为观察组和对照组各49例。对照组给予营养支持、限制液体摄入量、氧疗、使用外源性肺表面活性物质(PS)、控制感染等综合治疗,观察组在综合治疗基础上加用布地奈德混悬液0.5 mg加生理盐水1 m L氧气驱动雾化吸入10 min,每12 h一次,治疗5 d后评价疗效。结果:观察组总有效率87.8%,高于对照组的71.4%(P<0.05);观察组三凹征消失时间、呼吸频率恢复正常时间、吸氧时间均短于对照组(P<0.05)。结论:应用布地奈德氧气驱动雾化吸入辅助治疗NRDS早产儿能更快缓解呼吸困难,缩短用氧时间,提高临床疗效,值得临床推广应用。
Objective: To observe the effect of inhaled budesonide aerosol inhalation on respiratory distress symptom improvement time and oxygen inhalation time of neonatal respiratory distress syndrome (NRDS) and to evaluate the curative effect. Methods: A total of 98 preterm infants with NRDS who were born in our hospital from June 2011 to June 2013 were randomly divided into observation group (49 cases) and control group (49 cases). Control group was given nutritional support, limit liquid intake, oxygen therapy, the use of exogenous pulmonary surfactant (PS), infection control and other comprehensive treatment, the observation group on the basis of comprehensive treatment with budesonide suspension 0.5 mg Plus saline 1 m L oxygen inhalation inhalation 10 min, once every 12 h, 5 d after treatment to evaluate the efficacy. Results: The total effective rate in the observation group was 87.8%, which was higher than that in the control group (71.4%, P <0.05). The disappearance time, respiration frequency and time of oxygen inhalation in the observation group were shorter than those in the control group (P <0.05) . Conclusion: The use of budesonide oxygen-assisted nebulization to treat premature infants with NRDS can relieve dyspnea, shorten the time of oxygenation and improve clinical efficacy, which is worthy of clinical application.