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目的了解吸毒严重地区暗娼HIV和梅毒新发感染及队列保持情况。方法2004年12月至2005年1月,在四川省西昌市以社区为基础招募343名暗娼开展前瞻性队列研究,在6个月随访时进行HIV和梅毒血清抗体检测,估算HIV和梅毒血清抗体阳转率,以及分析队列本底的社会人口学和高危行为特征与队列6个月保持率的关系。结果暗娼队列6个月的HIV和梅毒血清抗体阳转率分别为1．00/100人年和6．23/100人年。队列6个月保持率为53．6%(184/343),在队列保持率影响因素的多因素logistic回归模型分析中,少数民族(OR=0．36,95% CI：0．18～0．74)、参加过艾滋病防治项目(OR=1．83,95% CI：1．17～2．86)、近6个月嫖客人数≥50人(OR=1．75,95%CI：1．11～2．77)和住所或工作场所变化(OR=0．56,95% CI：0．33～0．94)与6个月仍旧能随访的关系有统计学意义。结论该地区有高的暗娼梅毒新发感染率和高危性行为,汉族、参加过艾滋病防治项目及住所或工作场所稳定的暗娼队列保持率高。
Objective To understand the new infection and cohort status of HIV and syphilis in sex drug abusers. METHODS: From December 2004 to January 2005, 343 community-based female prostitutes were recruited in a prospective cohort study in Xichang, Sichuan Province. HIV and syphilis serum antibody tests were performed at 6-month follow-up. HIV and syphilis serum antibodies were estimated Positive rates, and the relationship between the socio-demographic and risk-behavior characteristics of the cohort and the 6-month cohort rate. Results The positive rate of HIV and syphilis serum antibody in the 6-month-old female sex workers cohort was 1.00 / 100 person-years and 6.23 / 100 person-years respectively. The 6-month retention rate was 53.6% (184/343). In the multivariate logistic regression analysis of the factors influencing cohort retention, the minority (OR = 0.36, 95% CI: 0.18-0 .74), participated in the AIDS prevention and treatment project (OR = 1.83,95% CI: 1.17-2.86), and the number of clients in the last 6 months was ≥50 (OR = 1.75,95% CI: 1 .11 ~ 2.77) and changes in residence or workplace (OR = 0.56, 95% CI: 0.33 ~ 0.94) were still able to follow up for 6 months. Conclusions There is a high incidence of syphilis and high-risk sexual behaviors among female sex workers in this area. The number of female sex workers who have participated in HIV / AIDS prevention and control programs and their residence or workplace is high.