论文部分内容阅读
VX是最为剧毒的有机磷神经毒剂。自60年代问世以来,已对它的理化性质和急性毒性进行过广泛的研究,但尚未见到经皮及皮下亚急性和慢性毒理方面的研究报道。VX作为持久性毒剂,研究其经皮肤染毒(包括皮下)的亚急性效应以及某些防治药物对中毒动物的作用,对评价其实用性具有一定的意义。 实验测得,VX对大白鼠的皮下LD_(50)值为9.6μg/kg,亚急性毒性的蓄积系数≤5.2,属中等或弱积蓄。VX亚急性中毒动物血清谷丙转氨酶活力测定结果显示:VX对雄性动物的肝功能损害比雌性动
VX is the most toxic organic phosphorus nerve agent. Since the advent of the 1960s, extensive research has been conducted on its physico-chemical properties and acute toxicity, but no studies have reported on subcutaneous and sub-acute and chronic toxicology. VX as a persistent agent, to study its subcutaneous effects of transdermal (including subcutaneous) subacute effects and the role of some of the prevention and treatment of drugs on the poisoned animals, to evaluate its usefulness has a certain significance. The experimental results showed that the subcutaneous LD_ (50) value of VX was 9.6μg / kg in rats, and the accumulation coefficient of subacute toxicity was ≤5.2, which was moderate or weak accumulation. VX subacute poisoning animal serum alanine aminotransferase activity measurement results showed that: VX on male animals, liver damage than female