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目的 评价骨髓涂片急性白血病(AL)细胞中P糖蛋白(Pgp)表达及其临床意义。方法 采用免疫组化SP法检测51例AL患者骨髓涂片白血病细胞中Pgp表达的阳性率。结果 51例ALPgp阳性率为275%,Pgp阳性的急性非淋巴细胞白血病以M4、M5表达率较高,而8例M3无1例阳性表达。初治组ALPgp阳性率为195%,复发难治组阳性率为600%,后者高于前者(P<005)。Pgp阳性者完全缓解率(CR率)为25%,而阴性者CR率为785%(P<005)。结论 Pgp过度表达与AL患者的化疗疗效及预后密切相关。
Objective To evaluate the expression of P-glycoprotein (Pgp) in bone marrow smear acute leukemia (AL) cells and its clinical significance. Methods Immunohistochemical SP method was used to detect the positive rate of Pgp expression in bone marrow smear leukemic cells in 51 AL patients. Results The positive rate of ALPgp in 27 cases was 275%. The expression of M4 and M5 in Pgp-positive acute non-lymphoblastic leukemia was higher, but there was no positive expression in 8 cases of M3. The positive rate of ALPGP in the untreated group was 195%, and the positive rate in the relapsed and refractory group was 600%. The latter was higher than the former (P < 005). The complete response rate (CR rate) of Pgp-positive patients was 25%, and the CR rate of negative patients was 785% (P < 005). Conclusion The overexpression of Pgp is closely related to the curative effect and prognosis of AL patients.