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20例男性不育症患者,计9例少精子症,8例无精子症,2例Klinefelter氏综合征和1例Kallmann氏综合征,年龄25～40岁,婚龄3～15年,均有3年以上婚后不育史。观察了使用D-丙~6-LRH乙基酰胺(LRH-A)的治疗效果。所有病人均采用LRH-A 10-25μg/日溶于0.9％生理盐水内作肌肉注射,连续10～50天(平均30天)。用药期间每15～30天作精子计数,停止治疗后随访三个月,部分病例作了睾丸活检及激素测定,以观察治疗效果。结果表明,LRH-A对该类男性不育症患者具有一定的疗效,但不十分理想。因此,尚有必要对病例的选择,合适用药方案的确立等作进一步的研究,这对提高疗效可能不无裨益。
20 male infertility patients, including 9 cases of oligozoospermia, 8 cases of azoospermia, 2 cases of Klinefelter’s syndrome and 1 case of Kallmann’s syndrome, aged 25 to 40 years old, age 3-15 years, both 3 Marital history of infertility. The therapeutic effect of using D-prop-6-LRH ethylamide (LRH-A) was observed. All patients were treated with LRH-A 10-25μg / day in 0.9% saline intramuscularly for 10 ~ 50 days (average 30 days). Sperm count was used every 15 to 30 days during treatment, followed up for three months after treatment was stopped. In some cases, testis biopsy and hormone test were performed to observe the therapeutic effect. The results showed that, LRH-A of such male infertility patients have a certain effect, but not very good. Therefore, there is still a need to further study the choice of cases and the establishment of appropriate drug regimens, which may not help to improve the efficacy.