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垂体生长激素和糖尿病及其血管并发症的关系问题于近几年被重新重视。由于生长激素抑制因子(Somatostatin)和生长激素介质(Somatomedins)的发现,促进了研究的开展,并进一步阐明了生长激素(以下简称GH)的生物效应。本文讨论GH与糖尿病及其血管并发症的关系。 1930年Houssay和Biasotti即注意到垂体对实验性糖尿病动物的作用,证明其病情因垂体切除而减轻,因垂体远侧部的植入或注入后而加重。1937年Young给完整的狗投以粗制的垂体前叶提取液后产生糖尿病。1949年Cotes等及Houssay等分别证实由垂体提取液致使动
The relationship between pituitary growth hormone and diabetes and its vascular complications has been re-emphasized in recent years. The discovery of somatostatin and somatomedins has facilitated the development of the study and further elucidated the biological effects of growth hormone (GH). This article discusses the relationship between GH and diabetes mellitus and its vascular complications. In 1930 Houssay and Biasotti noticed the effect of pituitary on experimental diabetic animals, demonstrating that their condition was alleviated by pituitary resection and worsened by implantation or injection of the distal part of pituitary gland. In 1937 Young gave the complete dog a crude extract of the anterior pituitary gland to produce diabetes. In 1949, Cotes et al. And Houssay et al. Respectively confirmed that the pituitary extract induced movement