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目的:评价治痔胶囊的止血作用和对肛周溃疡的治疗作用。方法:将实验小鼠随机分为空白对照组、阳性对照组(给予槐角丸1.4 g.kg-1)、高、中、低剂量组(分别给予治痔胶囊2.81,.4,0.7 g.kg-1),采用断尾法和玻片法分别测定出血时间和凝血时间;另外,通过大鼠制备肛周溃疡模型,并将造模大鼠随机分为模型组、阳性对照组(给予槐角丸0.88g.kg-1)、高、中、低剂量组(分别给予治痔胶囊1.75,0.88,0.44 g.kg-1),观察药物对肛周溃疡的治疗作用。结果:与空白组比较,治痔胶囊高、中剂量组能显著缩短出血时间和凝血时间;同时与模型组比较,治痔胶囊高中剂量组对大鼠肛周溃疡有明显的治愈效果。结论:治痔胶囊具有提高机体凝血功能,增强止血作用,并促进肛周溃疡愈合的功效。
Objective: To evaluate the hemostatic effect of Zhizhe Capsule and its therapeutic effect on perianal ulcer. Methods: The experimental mice were randomly divided into blank control group, positive control group (given Huaijiao pill 1.4 g.kg-1), high, medium and low dose groups (treated Zhizhe capsule 2.81, .4,0.7 g. kg-1). The bleeding time and clotting time were determined by the tail-end method and the slide method respectively. In addition, perianal ulcer model was prepared by rats and the model rats were randomly divided into model group, positive control group Angle pills 0.88g.kg-1), high, medium and low dose groups (were treated Zhizhe Capsule 1.75,0.88,0.44 g.kg-1), observed the effect of drugs on perianal ulcer. Results: Compared with the blank group, Zhizhi capsule high and medium dose groups can significantly shorten the bleeding time and clotting time; at the same time, compared with the model group, Zhizhi capsule high dose group had obvious curative effect on perianal ulcer in rats. Conclusion: Zhizhe Capsule has the effect of improving the body’s coagulation function, enhancing hemostasis and promoting the healing of perianal ulcer.