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目的:探讨孤立性纤维性肿瘤(SFTs)的临床病理及免疫表型特点和诊断、鉴别诊断及预后。方法:分析1例盆腔恶性孤立性纤维性肿瘤临床病理、影像学资料并复习文献。结果:梭型肿瘤细胞弥漫密集分布,细胞核分裂象多见,术后病理示盆腔恶性孤立性纤维性肿瘤伴多灶状坏死;免疫组化示CD34+、Vimentin+、Bcl-2+、CD99+、Desmin-、SMA-、CD17-等。术后1月余复查CT考虑肿瘤复发,给予放/化疗治疗后疗效欠佳。结论:及早发现、诊断及手术完整切除是治疗SFTs的最佳途径,统一治疗标准并给予特异性、个体化治疗方案对完善SFTs的治疗有重要的意义。
Objective: To investigate the clinicopathological and immunophenotypic characteristics, diagnosis, differential diagnosis and prognosis of solitary fibrous tumors (SFTs). Methods: One case of pelvic malignant solitary fibrous tumor was analyzed with clinicopathological and imaging data and reviewed the literature. Results: The spindle-shaped tumor cells were diffusely densely distributed and the mitotic figures were common. Postoperative pathology showed pelvic malignant solitary fibrous tumor with multifocal necrosis. The expression of CD34 +, Vimentin +, Bcl-2 +, CD99 +, Desmin- , SMA-, CD17- and the like. More than one month after surgery, CT review of tumor recurrence given radiotherapy / chemotherapy treatment ineffective. Conclusion: Early detection, diagnosis and complete resection of surgical resection are the best ways to treat SFTs. To standardize treatment and give specific and individualized treatment regimens is of great significance to improve the treatment of SFTs.