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目的 探讨α1 微球蛋白 (α1 MG)在急性有机磷农药中毒 (AOPP)肾损害早期诊断中的价值。方法 将 88例AOPP患者分成轻度中毒组、中度中毒组、重度中毒组 3组 ,另取 32例健康人为对照组。各组均行血、尿α1 MG ,血尿素氮 (BUN) ,肌酐 (SCr)测定 ,并进行对比分析。结果 AOPP轻度中毒组血、尿α1 MG与对照组比较差别显著(P <0 0 0 5 ) ,而BUN、SCr同对照组比较差异无显著性 (P >0 0 5 ) ,随AOPP中毒程度的加重 ,血、尿α1 MG ,BUN ,SCr逐渐上升。结论 血、尿α1 MG可作为AOPP肾损害早期诊断的敏感指标
Objective To investigate the value of α1 microglobulin (α1 MG) in the early diagnosis of renal damage induced by acute organophosphorus pesticide poisoning (AOPP). Methods 88 cases of AOPP patients were divided into mild poisoning group, moderate poisoning group and severe poisoning group, and another 32 healthy people as control group. The blood and urinary α1 MG, BUN and SCr were measured and compared in each group. Results Compared with control group, blood and urinary α1 MG in AOPP mild poisoning group showed significant difference (P <0 05), but there was no significant difference between BOP and SCN in control group (P> 0.05) The increase of blood, urine α1 MG, BUN, SCr gradually increased. Conclusion Blood and urine α1 MG can be used as sensitive indicators of early diagnosis of renal damage in AOPP