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实验用四氧嘧啶破坏Ｗｉｓｔａｒ大鼠胰腺诱发糖尿病模型，观察糖尿病人鼠心肌组织ＭＤＡ含量，ＳＯＤ和Ｎａ＋－Ｋ＋－ＡＴＰ酶活性的变化以及氧自由基清除剂（ＶｉｔＥ．亚硒酸钠）对糖尿病大鼠心肌的保护作用。结果表明：（１）糖尿病大鼠心肌组织ＭＤＡ含量显著增加（Ｐ＜０．０５），而心肌细胞膜上Ｎａ＋－Ｋ＋一ＡＴＰ酶的活性显著下降（Ｐ＜０．０１）．（２）ＶｉｔＥ和亚硒酸钠能显著降低糖尿病大鼠心肌组织ＭＤＡ含量，并能提高ＳＯＤ和Ｎａ＋－Ｋ＋－ＡＴＰ酶活性。以上结果说明糖尿病大鼠心肌组织的脂质过氧化反应可能是导致心肌细胞膜上Ｎａ＋－Ｋ＋－ＡＴＰ酶活性下降的原因之一
Alloxan was used to destroy the pancreas-induced diabetic model in Wistar rats. The changes of MDA content and the activities of SOD and Na + -K + -ATPase in myocardium of diabetic rats were observed, and the effects of oxygen free radical scavenger (VitE. Cardioprotective effects in rats. The results showed that: (1) The content of MDA in myocardium of diabetic rats increased significantly (P <0.05), while the activity of Na + -K + -ATPase in myocardial cells decreased significantly (P <0.01). (2) VitE and sodium selenite could significantly reduce the content of MDA in myocardial tissue of diabetic rats and increase the activities of SOD and Na + -K + -ATPase. These results suggest that myocardial lipid peroxidation in diabetic rats may be one of the reasons leading to the decrease of Na + -K + -ATPase activity in myocardial cell membrane