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目的:评价奥美拉唑治疗新生儿应激性溃疡的临床疗效和安全性。方法:本研究采用随机平行对照试验研究设计方案,将80例应激性溃疡新生儿受试者随机分为试验组和对照组各40例。试验组给予奥美拉唑胃管注入,0.6 mg/kg,1次/日,连续使用5 d。对照组给予去甲肾上腺素胃管注入,0.4 mg去甲肾上腺素加入生理盐水10 m L,每6 h 1次,连续使用5 d。两组均维持治疗直至胃回抽物不再有咖啡样液体或鲜红色的液体后,然后再行治疗1 d。疗效及安全性的评定采用总有效率、主要临床症状消失时间,胃液p H变化及不良反应发生情况。结果:治疗后,试验组患儿的总有效率为87.5%,对照组为47.5%,两组比较差异有统计学意义(P<0.01);试验组的主要临床症状消失时间短于对照组,差异有统计学意义(P<0.05);试验组患儿胃液p H为6.76±1.25,对照组为5.51±1.13,两组比较差异有统计学意义(P<0.05)。两组均未见明显不良反应(P>0.05)。结论:奥美拉唑胃管注入治疗新生儿应激性溃疡疗效优于去甲肾上腺素,两组均未见明显不良反应。
Objective: To evaluate the clinical efficacy and safety of omeprazole in the treatment of neonatal stress ulcer. Methods: In this study, a randomized controlled trial was designed to study the design of 80 stress ulcer neonates were randomly divided into experimental group and control group of 40 cases. The test group was given omeprazole tube injection, 0.6 mg / kg, 1 / day, continuous use of 5 d. The control group was given norepinephrine gastric tube injection, 0.4 mg norepinephrine added normal saline 10 m L, every 6 h 1, continuous use 5 d. The two groups were treated until the gastric juice was no longer coffee-like liquid or bright red liquid, and then re-treatment for 1 d. Efficacy and safety of the assessment of the total effective rate, the disappearance of the main clinical symptoms of time, p H changes in gastric juice and adverse reactions. Results: After treatment, the total effective rate was 87.5% in the experimental group and 47.5% in the control group, with significant difference between the two groups (P <0.01); the disappearance time of the main clinical symptoms in the experimental group was shorter than that in the control group, The difference was statistically significant (P <0.05). The gastric pH of the experimental group was 6.76 ± 1.25, while the control group was 5.51 ± 1.13. There was significant difference between the two groups (P <0.05). No obvious adverse reactions were found in both groups (P> 0.05). Conclusion: Omeprazole gastric tube injection is superior to norepinephrine in the treatment of stress ulcer in neonates, no obvious adverse reactions were found in both groups.