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目的:采用~(18)F 氟脱氧葡萄糖(~(18)F-fluorodeoxyglucose,~(18)F—FDG)正电子发射体层扫描(position emissiontomography,PET)心肌代谢显像技术评价分葱白提取物对猪缺血再灌注损伤心肌细胞活力的影响。方法:将24只猪随机分为假手术组、空白模型组、曲美他嗪组和葱白提取物组,每组6只。通过球囊封堵冠状动脉制备缺血再灌注模型。造模后第4天,葱白提取物组用葱白提取物灌胃(5.93 mg/kg,2次/d),曲美他嗪组灌胃曲美他嗪(0.36 mg/kg,2次/d).其他两组给同体积生理盐水,连续给药28 d。各组于最后一次给药后1 h 行~(18)F—FDG PET/CT 心肌显像检测,采用4级评分法评价相应节段心肌细胞活力。结果:分葱白提取物与曲美他嗪均可改善缺血再灌注心肌细胞活力而保护心肌细胞,与空白模型组比较,差异有统计学意义(P<0.01);葱白提取物组与曲美他嗪组比较,差异无统计学意义(P>0.05)。结论:分葱白提取物可以改善猪缺血再灌注心肌细胞活力。
OBJECTIVE: To evaluate the effect of 18F-18 F-fluorodeoxyglucose, 18 F-FDG PET on myocardium metabolic imaging Effects of Myocardial Cell Viability after Ischemia - Reperfusion Injury in Pigs. Methods: 24 pigs were randomly divided into sham operation group, blank model group, trimetazidine group and light blue extract group, with 6 rats in each group. Ischemia-reperfusion model was prepared by balloon occlusion of coronary arteries. On the 4th day after modeling, the extract of Allium sclerotiorum was gavaged with the extract of Scutellaria barbata (5.93 mg / kg, twice a day), and the trimetazidine group was fed with trimetazidine (0.36 mg / kg twice a day ) The other two groups were given the same volume of saline, continuous administration of 28 d. Each group was subjected to ~ (18) F-FDG PET / CT myocardial imaging 1 h after the last administration, and the myocardial cell viability was evaluated by 4-grade score method. Results: The scutellar extract and trimetazidine could both improve the myocardial cell viability during ischemia-reperfusion and protect the myocytes. Compared with the blank model group, the difference was statistically significant (P <0.01) Tharazine group, the difference was not statistically significant (P> 0.05). Conclusion: Fendeing extract can improve the myocardial viability of pigs during ischemia-reperfusion.