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对血液循环中的肾素——血管紧张素系统(R—A系统)人们早已有所认识。而对脑的R—A系统还知之不多,但有关的研究日益深入。本文主要简述当今有关脑的R—A系统的特性、功能及它们之间的相互作用的进展情况。 一、脑脊液循环和脑组织中的R—A系统 在脑组织中有肾素,但其分布不同于血液系统。而许多资料表明脑脊液循环中不存在肾素,但是,却有肾素底物。脑脊液中的肾素底物和血液中的肾素底物都是糖蛋白,
People have long been aware of the renin-angiotensin system (R-A system) in the blood circulation. The brain R-A system is also little known, but the research is more and more in-depth. This article summarizes the current state of the art about brain R-A systems, their function, and the progress of their interactions. First, the cerebrospinal fluid circulation and brain tissue in the R-A system has renin in brain tissue, but its distribution is different from the blood system. Many sources indicate that there is no renin in the cerebrospinal fluid circulation, but there is a renin substrate. The renin substrate in the cerebrospinal fluid and the renin substrate in the blood are glycoproteins,